LILRB1 Polyclonal Antibody for Human(Homo sapiens) | EIAab.comLILRB1 Polyclonal Antibody for Human(Homo sapiens)

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Index > Protein center > LILRB1(Gene name) > Human

LILRB1 (Gene name),

Leukocyte immunoglobulin-like receptor subfamily B member 1 (Protein name ), LIRB1_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

LILRB1(ILT2;LIR1;MIR7);

Protein name:

Leukocyte immunoglobulin-like receptor subfamily B member 1(LIR-1;Leukocyte immunoglobulin-like receptor 1);

Alternative:

Immunoglobulin-like transcript 2(ILT-2);CD85 antigen-like family member J;Monocyte/macrophage immunoglobulin-like receptor 7(MIR-7);

CD:

CD85j;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Binds PTPN6 when phosphorylated. Binds FCER1A and FCGR1A.

Function:

Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles. Receptor for H301/UL18, a human cytomegalovirus class I MHC homolog. Ligand binding results in inhibitory signals and down-regulation of the immune response. Engagement of LILRB1 present on natural killer cells or T-cells by class I MHC molecules protects the target cells from lysis. Interaction with HLA-B or HLA-E leads to inhibition of the signal triggered by FCER1A and inhibits serotonin release. Inhibits FCGR1A-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions.

Subcellular Location:

Membrane Single-pass type I membrane protein

Protein Attributes:

Sequence length:

650

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

600:

650:

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

UniGene:

Hs.667388

SMR:

Q8NHL6

STRING:

9606.ENSP00000315997

String:

Q8NHL6

MIM:

604811

KEGG:

hsa:10859

Uniprot:

Q8NHL6

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ELISA Kit for Human LIR-1

Cat.:

E9192h

Price:

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Manual:

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MSDS:

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Packing:

96T

Range:

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CLIA Kit for Human LIR-1

Cat.:

U9192h

Price:

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MSDS:

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Packing:

96T

Polyclonal Antibody for Human LIR-1

Cat.:

P9192Rb-h

Price:

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Packing:

40ug/0.2ml

Monoclonal Antibody for Human LIR-1

Protein for Human LIR-1

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"A new human gene complex encoding the killer cell inhibitory receptors and related monocyte/macrophage receptors."
Wagtmann N. , Rojo S. , Eichler E. , Mohrenweiser H. , Long E.O.
Curr. Biol.7:615-618(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4)
2.

"A novel immunoglobulin superfamily receptor for cellular and viral MHC class I molecules."
Cosman D. , Fanger N. , Borges L. , Kubin M. , Chin W. , Peterson L. , Hsu M.-L.
Immunity7:273-282(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 3);VARIANTS PRO-68; THR-142; ILE-155 AND LYS-625;INTERACTION WITH H301 AND PTPN6;PHOSPHORYLATION;TISSUE SPECIFICITY;FUNCTION
tissue: Lymphoblast.
3.

"Genomic organization of the human leukocyte immunoglobulin-like receptors within the leukocyte receptor complex on chromosome 19q13.4."
Liu W.R. , Kim J. , Nwankwo C. , Ashworth L.K. , Arm J.P.
Immunogenetics51:659-669(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1)
4.

"Alternative mRNA splicing creates transcripts encoding soluble proteins from most LILR genes."
Jones D.C. , Roghanian A. , Brown D.P. , Chang C. , Allen R.L. , Trowsdale J. , Young N.T.
Eur. J. Immunol.39:3195-3206(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 5);ALTERNATIVE SPLICING;SUBCELLULAR LOCATION (ISOFORM 5);VARIANTS PRO-68; THR-93; THR-142 AND ILE-155
5.

"LILRB1 polymorphism and surface phenotypes of natural killer cells."
Davidson C.L. , Li N.L. , Burshtyn D.N.
Hum. Immunol.71:942-949(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANTS PRO-68; THR-93; THR-142; ILE-155 AND LYS-625
6.

Canavez F.C.
Submitted (2000-07) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2)
7.

"The DNA sequence and biology of human chromosome 19."
Grimwood J. , Gordon L.A. , Olsen A.S. , Terry A. , Schmutz J. , Lamerdin J.E. , Hellsten U. , Goodstein D. , Couronne O. , Tran-Gyamfi M. , Aerts A. , Altherr M. , Ashworth L. , Bajorek E. , Black S. , Branscomb E. , Caenepeel S. , Carrano A.V. , more...
Nature428:529-535(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
8.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1);VARIANTS PRO-68; THR-142; ILE-155 AND LYS-625
tissue: B-cell.
9.

"The MHC class I binding proteins LIR-1 and LIR-2 inhibit Fc receptor-mediated signaling in monocytes."
Fanger N.A. , Cosman D. , Peterson L. , Braddy S.C. , Maliszewski C.R. , Borges L.
Eur. J. Immunol.28:3423-3434(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PTPN6 AND FCGR1A;PHOSPHORYLATION;TISSUE SPECIFICITY;FUNCTION
10.

"The inhibitory receptor LIR-1 uses a common binding interaction to recognize class I MHC molecules and the viral homolog UL18."
Chapman T.L. , Heikeman A.P. , Bjorkman P.J.
Immunity11:603-613(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH HHV-5 PROTEIN UL18
11.

"Mutational analysis of immunoreceptor tyrosine-based inhibition motifs of the Ig-like transcript 2 (CD85j) leukocyte receptor."
Bellon T. , Kitzig F. , Sayos J. , Lopez-Botet M.
J. Immunol.168:3351-3359(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT TYR-533; TYR-614 AND TYR-644;MUTAGENESIS OF TYR-533; TYR-562; TYR-614 AND TYR-644;INTERACTION WITH FCER1A;FUNCTION
12.

"Crystal structure and ligand binding properties of the D1D2 region of the inhibitory receptor LIR-1 (ILT2)."
Chapman T.L. , Heikema A.P. , West A.P. Jr. , Bjorkman P.J.
Immunity13:727-736(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS) OF 25-221

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